Suspected Adverse Methylphenidate–imipramine Interactions in Children

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:   Frankp@chiro.org

FROM: J Dev Behav Pediatr 1986;   7 (4) Aug:   265–267

Grob CS, Coyle JT

Two cases are presented which illustrate the dangers inherent in utilizing a polypharmacy approach in treating children with psychotropic medication. In each case, severe adverse effects, including cognitive and mood deterioration, were experienced by the child when treated with a combination of methylphenidate and imipramine. Possible mechanisms at the neurotransmitter level are described as postulated determinants for this pharmacological interaction.

Return to the ADD/ADHD Page

Since 6-08-2001