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Table 5

Sensitivity analyses by treatment group*

Treatment groupMean cost*(£)Mean adjusted QALYs*Incremental cost effectiveness ratio to nearest £100 or comment
Excluding participants with health care costing more than £2000 over 12 months (n=1266)



Best care in general practice
277
0.621

Best care plus exercise
322
0.632
Subject to extended dominance by manipulation
Best care plus manipulation and exercise
403
0.647
Subject to extended dominance by manipulation
Best care plus manipulation
411
0.665
£3000 relative to best care
NHS provides manipulation for only 50% of patients (n=1287)



Best care in general practice
346
0.616

Best care plus exercise
486
0.628
Subject to extended dominance by manipulation and exercise
Best care plus manipulation and exercise
537
0.645
£6600 relative to best care
Best care plus manipulation
624
0.655
£8700 relative to manipulation and exercise
Manipulation provided only in private premises (n=1287)



Best care in general practice
346
0.616

Best care plus exercise
486
0.628
Subject to extended dominance by manipulation and exercise
Best care plus manipulation and exercise
595
0.645
£8600 relative to best care
Best care plus manipulation 701 0.655 £10 600 relative to manipulation and exercise

QALY=quality adjusted life year.

*Markov Chain Monte Carlo estimates from bivariate hierarchical multilevel model.
Estimated by analysis of covariance with adjustment for baseline EQ-5D score and then rounded to three significant figures.
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