BIODISCRIMINATION OF ALPHA-TOCOPHEROL STEREOISOMERS IN HUMANS AFTER ORAL ADMINISTRATION

Biodiscrimination of Alpha-tocopherol Stereoisomers
in Humans After Oral Administration

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:
    Frankp@chiro.org

FROM:   Am J Clin Nutr. 1997 (Mar);   65 (3): 785–789 ~ FULL TEXT

Kiyose C, Muramatsu R, Kameyama Y, Ueda T, Igarashi O.

Institute of Environmental Science for Human Life,
Ochanomizu University,
Tokyo, Japan.
ckiyose@cc.ocha.ac.jp


We investigated changes in the concentrations of the stereoisomers of alpha-tocopherol in serum and lipoproteins in seven normal, healthy women aged 21-37 y who had received oral administration of natural and synthetic alpha-tocopheryl acetate. This study was conducted in three separate periods of 28 d each; there was a 3-mo washout period between each experimental period. During the first period the subjects were administered a daily dose of 100 mg RRR-alpha-tocopherol/d, whereas in the second and third periods 100 mg all-rac-alpha-tocopheryl acetate/d and 300 mg all-rac-alpha-tocopheryl acetate/d were given, respectively. Blood samples were collected 3 d before each treatment and 1, 3, 7, 14, and 28 d after treatment. alpha-Tocopherol stereoisomer concentrations in serum and lipoproteins (very-low-, low-, and high-density lipoproteins) were determined by the chiral HPLC method. The bioavailability of RRR-alpha-tocopherol was greater than that of all-rac-alpha-tocopheryl acetate. When bioavailability was estimated from the increase in the concentration of RRR- or all-rac-alpha-tocopherol in serum, bioavailability of RRR-alpha-tocopherol administered at 100 mg/d was not different from that of all-rac-alpha-tocopheryl acetate administered at 300 mg/d. 2R-Isomers and small amounts of 2S-isomers were detected in the serum lipoproteins of subjects administered all-rac-alpha-tocopheryl acetate.


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