Am J Med 1993 (Jun); 94 (6): 632–635
Jain AK, Vargas R, Gotzkowsky S, McMahon FG
Clinical Research Center,
New Orleans, Louisiana 70112
PURPOSE: To assess the effects of standardized garlic
powder tablets on serum lipids and lipoproteins, glucose, and
SUBJECTS AND METHODS: Forty-two healthy adults (19 men,
23 women), mean age of 52 +/- 12 years, with a serum total
cholesterol (TC) level of greater than or equal to 220 mg/dL
received, in a randomized, double-blind fashion, either 300 mg
three times a day of standardized garlic powder in tablet form or
placebo. Diets and physical activity were unchanged. This study
was conducted in an outpatient, clinical research unit.
RESULTS: The baseline serum TC level of 262 +/- 34 mg/dL
was reduced to 247 +/- 40 mg/dL (p < 0.01) after 12 weeks of
standard garlic treatment. Corresponding values for placebo were
276 +/- 34 mg/dL before and 274 +/- 29 mg/dL after placebo
treatment. Low-density lipoprotein cholesterol (LDL-C) was
reduced by 11% by garlic treatment and 3% by placebo (p < 0.05).
There were no significant changes in high-density lipoprotein
cholesterol, triglycerides, serum glucose, blood pressure, and
other monitored parameters.
CONCLUSIONS: Treatment with standardized garlic 900 mg/d
produced a significantly greater reduction in serum TC and LDL-C
than placebo. The garlic formulation was well tolerated without
any odor problems.