Co-ingestion of Protein and Leucine Stimulates Muscle Protein Synthesis Rates to the Same Extent in Young and Elderly Lean Men
 
   

Co-ingestion of Protein and Leucine
Stimulates Muscle Protein Synthesis
Rates to the Same Extent
in Young and Elderly Lean Men

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:
   Frankp@chiro.org
 
   

From American Journal of Clinical Nutrition 2006 (Sep);   84 (3):   623632

Koopman R, Verdijk L, Manders RJ, Gijsen AP, Gorselink M,
Pijpers E, Wagenmakers AJ, van Loon LJ

Department of Human Biology,
Maastricht University,
Maastricht, Netherlands.
r.koopman@hb.unimaas.nl


BACKGROUND:   The progressive loss of skeletal muscle mass with aging is attributed to a disruption in the regulation of skeletal muscle protein turnover.

OBJECTIVE:   We investigated the effects on whole-body protein balance and mixed-muscle protein synthesis rates of the ingestion of carbohydrate with or without protein and free leucine after simulated activities of daily living.

DESIGN:   Eight elderly (75 +/- 1 y) and 8 young (20 +/- 1 y) lean men were randomly assigned to 2 crossover experiments in which they consumed either carbohydrate (CHO) or carbohydrate plus protein and free leucine (CHO+Pro+Leu) after performing 30 min of standardized activities of daily living. Primed, continuous infusions with L-[ring-13C6]phenylalanine and L-[ring-2H2]tyrosine were applied, and blood and muscle samples were collected to assess whole-body protein turnover and the protein fractional synthetic rate in the vastus lateralis muscle over a 6-h period.

RESULTS:   Whole-body phenylalanine and tyrosine flux were significantly higher in the young than in the elderly men (P < 0.01). Protein balance was negative in the CHO experiment but positive in the CHO+Pro+Leu experiment in both groups. Mixed-muscle protein synthesis rates were significantly greater in the CHO+Pro+Leu than in the CHO experiment in both the young (0.082 +/- 0.005%/h and 0.060 +/- 0.005%/h, respectively; P < 0.01) and the elderly (0.072 +/- 0.006%/h and 0.043 +/- 0.003%/h, respectively; P < 0.01) subjects, with no significant differences between groups.

CONCLUSIONS:   Co-ingestion of protein and leucine with carbohydrate after activities of daily living improves whole-body protein balance, and the increase in muscle protein synthesis rates is not significantly different between lean young and elderly men.


Return to the LEUCINE Page

Since 1-12-2007

         © 19952017 ~ The Chiropractic Resource Organization ~ All Rights Reserved