Efficacy and Tolerability of Boswellia serrata Extract in Treatment of Osteoarthritis of Knee--A Randomized Double Blind Placebo Controlled Trial
 
   

Efficacy and Tolerability of Boswellia
serrata Extract in Treatment of
Osteoarthritis of Knee --
A Randomized Double Blind
Placebo Controlled Trial

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:
   Frankp@chiro.org
 
   

FROM:   Phytomedicine 2003 (Jan);   10 (1):   37

Kimmatkar N, Thawani V, Hingorani L, Khiyani R

MS Orthopedics,
Indira Gandhi Medical College,
Nagpur, India


Osteoarthritis is a common, chronic, progressive, skeletal, degenerative disorder, which commonly affects the knee joint. Boswellia serrata tree is commonly found in India. The therapeutic value of its gum (guggulu) has been known. It posses good anti-inflammatory, anti-arthritic and analgesic activity. A randomized double blind placebo controlled crossover study was conducted to assess the efficacy, safety and tolerability of Boswellia serrata Extract (BSE) in 30 patients of osteoarthritis of knee, 15 each receiving active drug or placebo for eight weeks. After the first intervention, washout was given and then the groups were crossed over to receive the opposite intervention for eight weeks. All patients receiving drug treatment reported decrease in knee pain, increased knee flexion and increased walking distance. The frequency of swelling in the knee joint was decreased. Radiologically there was no change. The observed differences between drug treated and placebo being statistically significant, are clinically relevant. BSE was well tolerated by the subjects except for minor gastrointestinal ADRs. BSE is recommended in the patients of osteoarthritis of the knee with possible therapeutic use in other arthritis.


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