Table 3

Summary of male serum biochemical data in the rat subchronic 13-week oral toxicity study.

MalesGlucose (mmol/l)Urea (mmol/l)Creat. (umol/l)Na+ (mmol/l)K+ (mmol/l)Cl (mmol/L)Ca++ (mmol/l)P (mmol/l)T. Chol. (mmol/l)
Control6.94 ± 0.956.80 ± 0.9454.62 ± 6.58145.61 ± 1.015.28 ± 0.49105.19 ± 1.492.47 ± 0.052.42 ± 0.251.46 ± 0.26
100 mg/kg/day6.81 ± 1.227.67 ± 1.2858.85 ± 9.79145.20 ± 0.515.06 ± 0.45104.66 ± 1.452.41 ± 0.062.39 ± 0.181.58 ± 0.15
300 mg/kg/day6.85 ± 1.446.98 ± 0.6254.69 ± 4.46144.81 ± 0.714.99 ± 0.46104.7 ± 1.452.43 ± 0.062.34 ± 0.171.60 ± 0.36
1000 mg/kg/day6.74 ± 0.906.81 ± 0.6354.81 ± 4.13145.19 ± 1.075.35 ± 0.35104.20 ± 1.162.40 ± 0.082.360 ± 0.171.68 ± 0.28


MalesT. Prot. (g/L)Alb (g/L)AST (U/L0)ALT (U/L)ALKP (U/L)GGT (U/L)T. Bil. (umol/L)A/G

Control55.84 ± 1.5829.79 ± 1.09119.20 ± 13.7453.00 ± 4.3290.90 ± 13.476.00 ± 0.003.49 ± 0.211.16 ± 0.07
100 mg/kg/day54.69 ± 2.1228.68 ± 2.09128.40 ± 19.4054.60 ± 9.3787.60 ± 12.576.00 ± 0.003.04 ± 0.361.10 ± 0.08
300 mg/kg/day53.95 ± 2.0228.08 ± 1.43120.70 ± 16.6754.80 ± 3.2983.50 ± 11.256.00 ± 0.003.47 ± 0.631.08 ± 0.04
1000 mg/kg/day55.98 ± 1.6928.96 ± 0.97134.70 ± 32.4455.80 ± 4.1890.50 ± 16.576.00 ± 0.003.32 ± 0.721.08 ± 0.06

Values are mean ± S.D.

∗∗p < 0.01.

p < 0.05.
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