Ginkgolides Antagonizing Some Effects of Platelet-activating Factor in Vitro

This section is compiled by Frank M. Painter, D.C.
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FROM:   Zhongguo Zhong Xi Yi Jie He Za Zhi 1995;   15 (10) Oct:   606-8

Dong JC, Li M, Shi ZY

Huashan Hospital, Shanghai Medical University


The mixture of platelet-activating factor (PAF) and platelets produced significant contraction of guinea pigs' bronchus, while the contraction induced by PAF alone was mild relatively, the IC50 were 6.14 x 10(-7) mol/L and 6.32 x 10(-4) mol/L respectively. There was significant difference between these two groups (P < 0.05). When the platelets were pre-incubated with ginkgolides for 10 minutes in Tris-Tyrode's buffered saline, effects of the PAF and platelets mixture were significantly inhibited (P < 0.01). Exposure of guinea pigs' bronchus to PAF in vitro resulted in a loss of beta-adrenergic receptors and responses to isoproterenol, and this effect of PAF was prevented by prior incubation of the guinea pigs' bronchus with ginkgolides (P < 0.05). The results showed ginkgolides were a potent PAF antagonist.

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