Levels of Reduced and Oxidized Coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the CSF of Patients with Alzheimer's Disease Demonstrate That Mitochondrial Oxidative Damage and/or Oxidative DNA Damage Contributes to the Neurodegenerative Process
 
   

Levels of Reduced and Oxidized Coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the CSF of Patients with Alzheimer's Disease Demonstrate That Mitochondrial Oxidative Damage and/or Oxidative DNA Damage Contributes to the Neurodegenerative Process

This section is compiled by Frank M. Painter, D.C.
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   Frankp@chiro.org
 
   

FROM: J Neurol 2010 (Mar);   257 (3):   399-404

Isobe C, Abe T, Terayama Y

Department of Neurology,
Iwate Medical University,
19-1 Uchimaru, Morioka,
Iwate, 020-0805, Japan,
chiso@apost.plala.or.jp


To investigate the possibility that mitochondrial oxidative damage, oxidative DNA damage or both contribute to the neurodegenerative process of Alzheimer's disease (AD), we employed high-performance liquid chromatography using an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q-10 (CoQ-10) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the cerebrospinal fluid (CSF) of 30 patients with AD and in 30 age-matched controls with no neurological disease. The percentage of oxidized/total CoQ-10 (%CoQ-10) in the CSF of the AD group (78.2 +/- 18.8%) was significantly higher than in the control group (41.3 +/- 10.4%) (P < 0.0001). The concentration of 8-OHdG in the CSF of AD patients was greater than in the CSF of controls (P < 0.0001) and was positively correlated with the duration of illness (r (s) = 0.95, P < 0.0001). The %CoQ-10 was correlated with concentrations of 8-OHdG in the CSF of AD patients (r (s) = 0.66, P < 0.001). The present study suggests that both mitochondrial oxidative damage and oxidative DNA damage play important roles in the pathogenesis of early AD development.


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