Efficacy of Lactobacillus GG in Prevention of Nosocomial Diarrhea in Infants
 
   

Efficacy of Lactobacillus GG in Prevention of
Nosocomial Diarrhea in Infants

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:
   Frankp@chiro.org
 
   

FROM:   J Pediatr 2001;   138 (3) Mar:   361365

Szajewska H, Kotowska M, Mrukowicz JZ, Armanska M, Mikolajczyk W

Department of Pediatric Gastroenterology and Nutrition,
The Medical University of Warsaw,
Warsaw, Poland


OBJECTIVE:   Nosocomial diarrhea is a major problem in pediatric hospitals worldwide. We evaluated the efficacy of orally administered Lactobacillus GG (LGG) in the prevention of this disease in young children.

STUDY DESIGN:   Eighty-one children aged 1 to 36 months who were hospitalized for reasons other than diarrhea were enrolled in a double-blind trial and randomly assigned at admission to receive LGG (n = 45) at a dose of 6 x 10(9) colony-forming units or a comparable placebo (n = 36) twice daily orally for the duration of their hospital stay.

RESULTS:   LGG reduced the risk of nosocomial diarrhea (> or =3 loose or watery stools/24 h) in comparison with placebo (6.7% vs 33.3%; relative risk: 0.2; [95% CI: 0.06-0.6]; number needed to treat: 4 [95% CI: 2-10]). The prevalence of rotavirus infection was similar in LGG and placebo groups (20% vs 27.8%, respectively; relative risk: 0.72; 95% CI: 0.33-1.56). However, the use of LGG compared with placebo significantly reduced the risk of rotavirus gastroenteritis (1/45 [2.2%] vs 6/36 [16.7%], respectively; relative risk: 0.13; 95% CI: 0.02-0.79; number needed to treat: 7; 95% CI: 3-40).

CONCLUSIONS:   Prophylactic use of LGG significantly reduced the risk of nosocomial diarrhea in infants, particularly nosocomial rotavirus gastroenteritis.


Return to the ACIDOPHILUS Page

Since 6-01-2001

         © 19952017 ~ The Chiropractic Resource Organization ~ All Rights Reserved