Rheumatoid Arthritis & Essential Fatty Acids

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:   Frankp@chiro.org

If there are terms in these articles you don't understand, you can get a definition from the Merriam Webster Medical Dictionary.   If you want information about a specific disease, you can access the Merck Manual.   Search Pub Med for more abstracts on this topic.


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Rheumatoid Arthritis & EFA Articles

   Omega-3s May Help Rheumatoid Arthritis
          Omega-3 fatty acid-rich fish oil supplements may provide modest improvement in rheumatoid arthritis (RA), according to a double-blind, placebo-controlled study conducted at the University of Newcastle in Australia. In this study, 50 people with RA were randomly assigned to take either 40 mg/kg body weight of fish oil (containing 60 percent omega-3 fatty acids) or placebo daily for 15 weeks. The fish oil group had an average age of 54 and an average disease duration of 12 years, whereas the placebo group was 60 years old on average and had RA for an average of 15 years. Because omega-6 fatty acids, found in most vegetable oils, compete with omega-3 fatty acids, the researchers included only subjects who generally ate less than 10 g/day of omega-6 fatty acids.

Rheumatoid Arthritis & EFA Abstracts

   N-3 Fatty Acid Supplements in Rheumatoid Arthritis
           Am J Clin Nutr 2000 (Jan);   71 (1 Suppl):   349S–351S
           Ingestion of dietary supplements of n-3 fatty acids has been consistently shown to reduce both the number of tender joints on physical examination and the amount of morning stiffness in patients with rheumatoid arthritis. In these cases, supplements were consumed daily in addition to background medications and the clinical benefits of the n-3 fatty acids were not apparent until they were consumed for > or =12 wk. It appears that a minimum daily dose of 3 g eicosapentaenoic (EPA) and docosahexaenoic acids is necessary to derive the expected benefits.


   Validation of a Meta-analysis:
The Effects of Fish Oil in Rheumatoid Arthritis
J Clin Epidemiol 1995 (Nov);   48 (11):   1379–1390
The purpose of this study was to validate the results of a meta-analysis showing the efficacy of fish oil in rheumatoid arthritis with the results of a re-analysis of the complete primary data set.


   Effects of Fish Oil Supplementation on Non-steroidal Anti-inflammatory Drug Requirement in Patients with Mild Rheumatoid Arthritis -- A Double-blind Placebo Controlled Study
Br J Rheumatol 1993 (Nov);   32 (11):   982–989
These patients were able to reduce their NSAID requirement without experiencing any deterioration in the clinical and laboratory parameters of RA activity.


   Fish-oil Fatty Acid Supplementation in Active Rheumatoid Arthritis: A Double-blinded, Controlled, Crossover Study
Ann Intern Med 1987 (Apr);   106 (4):   497–503
Fish-oil ingestion results in subjective alleviation of active rheumatoid arthritis and reduction in neutrophil leukotriene B4 production. Further studies are needed to elucidate mechanisms of action and optimal dose and duration of fish-oil supplementation.

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Since 2-01-1998

Updated 1-06-2008