SYNTHETIC AS COMPARED WITH NATURAL VITAMIN E IS PREFERENTIALLY EXCRETED AS ALPHA-CEHC IN HUMAN URINE: STUDIES USING DEUTERATED ALPHA-TOCOPHERYL ACETATES

Synthetic As Compared With Natural Vitamin E
Is Preferentially Excreted As Alpha-CEHC in
Human Urine: Studies Using Deuterated
Alpha-tocopheryl Acetates

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:
    Frankp@chiro.org

FROM:   FEBS Lett. 1998 (Oct 16);   437 (1-2):   145–148 ~ FULL TEXT

Traber MG1, Elsner A, Brigelius-Flohι R.

Linus Pauling Institute,
Oregon State University,
Corvallis 97330, USA.
maret.traber@orst.edu


Alpha-CEHC (2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman) is a urinary vitamin E metabolite with a truncated phytyl tail. To test whether natural and synthetic vitamin E are similarly converted to alpha-CEHC, 6 humans consumed 150 mg each RRR-alpha-[5-(C2H3)]- and all rac-alpha-[5,7(C2H3)2]-tocopheryl acetates (d3RRR-alpha- and d6all rac-alpha-tocopheryl acetates, respectively). Plasma was collected at 0, 6, 12 and 24 h; urine (24 h) at 0, 1, 2, 3, 4 and 8 days. Following dosing, plasma was enriched with d3RRR-alpha-tocopherol, while urine was enriched with alpha-CEHC derived from d6all rac-alpha-tocopherol. Thus, synthetic compared with natural vitamin E is preferentially metabolized to alpha-CEHC and excreted.


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