Effect of Cocoa Products on Blood Pressure:
Systematic Review and Meta-analysis
American Journal of Hypertension 2010 (Jan); 23 (1): 97–103
The evidence supporting the antihypertensive effects of cocoa has been building over the last few years, and this systematic review and meta-analysis of 10 randomized controlled trials, comprising 297 individuals confirms the BP-lowering capacity of flavanol-rich cocoa products. The high level of flavanols found in the cocoa plant is believed to be responsible for the lowering of blood pressure.
Flavonoids: Recent Advances as Anticancer Drugs
Recent Pat Anticancer Drug Discov 2010 (Jan 21) [Epub ahead of print]
Flavonoids belong to polyphenolic secondary metabolites with broad-spectrum pharmacological activities and extensive biological effects, and the most prominent activity is their potential role as anticancer agents. In recent years, flavonoids and their synthetic analogues have been intensely investigated in the treatment of ovarian, breast, cervical, pancreatic, and prostate cancer.
Cyclopamine and Quercetin Suppress the Growth of Leukemia
and Lymphoma Cells
Anticancer Res 2009 (Nov); 29 (11): 4629–4632
Cyclopamine and quercetin suppress the growth of a number of leukemia and lymphoma cells. This finding suggests the potential use of these compounds in molecularly-targeted therapy for leukemia and lymphoma.
Effects of Daily Oral Administration of Quercetin Chalcone and Modified Citrus Pectin on Implanted Colon-25 Tumor Growth in Balb-c Mice
Alternative Medicine Review 2000 (Dec); 5 (6): 546–552 ~ FULL TEXT
Previous research has confirmed that quercetin exhibits antitumor properties, likely due to immune stimulation, free radical scavenging, alteration of the mitotic cycle in tumor cells, gene expression modification, anti-angiogenesis activity, or apoptosis induction, or a combination of these effects. MCP has inhibited metastases in animal studies of prostate cancer and melanoma. To date, no study has demonstrated a reduction in solid tumor growth with MCP, and there is no research into the antitumor effect of QC. This study examines the effects of MCP and QC on the size and weight of colon-25 tumors implanted in balb-c mice.
Flavonoids Apigenin and Quercetin Inhibit Melanoma Growth
and Metastatic Potential
Int J Cancer 2000 (Aug); 87 (4): 595–600
In conclusion, quercetin and apigenin inhibit melanoma growth and invasive and metastatic potential; therefore, they may constitute a valuable tool in the combination therapy of metastatic melanoma.
Antioxidants and Cancer III: Quercetin
Alternative Medicine Review 2000 (Jun); 5 (3): 196–208 ~ FULL TEXT
Quercetin is a flavonoid molecule ubiquitous in nature. A number of its actions make it a potential anti-cancer agent, including cell cycle regulation, interaction with type II estrogen binding sites, and tyrosine kinase inhibition. Quercetin appears to be associated with little toxicity when administered orally or intravenously. Much in vitro and some preliminary animal and human data indicate quercetin inhibits tumor growth. More research is needed to elucidate the absorption of oral doses and the magnitude of the anti-cancer effect.
Oligomeric Proanthocyanidin Complexes: History, Structure,
and Phytopharmaceutical Applications
Alternative Medicine Review 2000 (Apr); 5 (2): 144–151 ~ FULL TEXT
Considerable recent research has explored therapeutic applications of oligomeric proanthocyanidin complexes (OPCs), naturally occurring plant metabolites widely available in fruits, vegetables, nuts, seeds, flowers, and bark. OPCs are primarily known for their antioxidant activity. However, these compounds have also been reported to demonstrate antibacterial, antiviral, anticarcinogenic, anti-inflammatory, anti-allergic, and vasodilatory actions. In addition, they have been found to inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems including phospholipase A2, cyclooxygenase, and lipoxygenase.
Flavonoids Inhibit Cell Growth and Induce Apoptosis
in B16 Melanoma 4A5 Cells
Biosci Biotechnol Biochem 2000 (Sep); 64(9): 1813–20
We investigated the growth inhibitory activity of several flavonoids, including apigenin, luteolin, kaempherol, quercetin, butein, isoliquiritigenin, naringenin, genistein, and daizein against B16 mouse melanoma 4A5 cells.
Quercetin: A Review of Clinical Applications
Natural Medicine Online July 2000
Quercetin is frequently used therapeutically in allergic conditions, including asthma and hayfever, eczema, and hives. Additional clinical uses include treatment of gout, pancreatitis and prostatitis, which are also, in part, inflammatory conditions. The common link is its ability to mediate production and manufacture of pro-inflammatory compounds.
Alternative Medicine Review 1998 (Apr); 3 (2): 140–143 ~ FULL TEXT
Quercetin appears to have many beneficial effects on human health, including cardiovascular protection, anti-cancer activity, anti-ulcer effects, anti-allergy activity, cataract prevention, antiviral activity, and anti-inflammatory effects.
Antioxidant Flavonoids: Structure, Function and Clinical Usage
Alternative Medicine Review 1996 (Jul); 1 (2): 103–111 ~ FULL TEXT
Flavonoids have been shown to have anti-bacterial, anti-inflammatory, antiallergic, antimutagenic, antiviral, antineoplastic, anti-thrombotic, and vasodilatory activity.
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