Zinc Intake From Supplements and Diet and Prostate Cancer
Nutrition and Cancer 2009; 61 (2): 206–215
Researchers at the Fred Hutchinson Cancer Research Center and the University of Washington evaluated the association between dietary and supplemental zinc and prostate cancer in 35,242 men participating in the VITAL cohort, a study specifically designed to evaluate the impact of dietary supplements on cancer risk. In this study, long-term supplemental zinc intake was associated with reduced risk of clinically relevant advanced disease.
Zinc Supplementation Decreases Incidence of Infections in the Elderly:
Effect of Zinc on Generation of Cytokines and Oxidative Stress
Am J Clin Nutr 2007 (Mar); 85 (3): 837–844
In this randomized, double-blind, placebo-controlled trial of zinc supplementation, the incidence of infections was significantly lower, plasma zinc was significantly higher, and generation of tumor necrosis factor alpha and oxidative stress markers was significantly lower in the zinc-supplemented than in the placebo group.
Effect of Zinc Supplementation on Growth and Body Composition
in Children with Sickle Cell Disease
Amer J Clin Nutrit 2002 (Feb); 75 (2): 300–307
Thirty-eight children completed the study. No significant differences were observed at baseline. After 12 mo, the zinc group had significantly greater mean (±SE) increases in height (0.66 ± 0.29 cm/y), sitting height (0.97 ± 0.40 cm/y), knee height (3.8 ± 1.2 mm/y), and arm circumference z scores (0.27 ± 0.12 cm/y). Height-for-age and weight-for-age z scores decreased significantly by 0.11 ± 0.04 and 0.13 ± 0.05, respectively, in the control group but did not change significantly in the zinc group.
Zinc Supplementation in Infants Born Small for Gestational Age
Reduces Mortality: A Prospective, Randomized, Controlled Trial
Pediatrics 2001 (Dec); 108 (6): 1280–1286
Zinc supplementation in small for gestational age infants can result in a substantial reduction in infectious disease mortality.
Nutrients and HIV Part II: Vitamins A and E, Zinc, B-Vitamins, and Magnesium
Alternative Medicine Review 2000 (Feb); 5 (1): 39–51 – FULL TEXT
Vitamin A deficiency is a common occurrence in HIV infection, and serum levels appear to decrease as the disease progresses. (1) Low serum levels of vitamin A were found in 12-19 percent of HIV-positive, asymptomatic subjects in the United States. (1,2) Vitamin A deficiency was found in an increasingly higher proportion of women than men (p< .01) in an HIV-infected, intravenous drug-using population. (3)
Zinc Gluconate Lozenges for Treating the Common Cold:
A Randomized, Double-blind, Placebo-controlled Study
Ann Intern Med 1996 (Jul 15); 125 (2): 81–88
Zinc gluconate in the form and dosage studied significantly reduced the duration of symptoms of the common cold. The mechanism of action of this substance in treating the common cold remains unknown. Individual patients must decide whether the possible beneficial effects of zinc gluconate on cold symptoms outweigh the possible adverse effects.
Nutrient Intake of Patients with Rheumatoid Arthritis is Deficient
in Pyridoxine, Zinc, Copper, and Magnesium
J Rheumatol 1996 (Jun); 23 (6): 990–994
Patients with RA ingest too much total fat and too little PUFA and fiber. Their diets are deficient in pyridoxine, zinc and magnesium vs the RDA and copper and folate vs the TAD. These observations, also documented in previous studies, suggest that routine dietary supplementation with multivitamins and trace elements is appropriate in this population.
Immune and Nutritional Recovery of Severely Malnourished Children
Cahiers Sante 1996; 6 (4): 201–208
Children receiving zinc attained immunological recovery within one month, whereas children not receiving zinc took two months. Thus zinc hastened immunological recovery concomitant with nutritional recovery such that the duration of hospitalization could be halved: after one month of this immuno-nutritional treatment, malnourished children appear to be sufficiently healthy to face their pathogenic home environment.
The Biological Significance of Zinc
Anaesthesist 1975 (Aug); 24 (8): 329–342
Zinc takes part in the catalytic function of many metalloenzymes. In others it plays a role in conformational stability. In zinc deficient animals protein synthesis is disturbed. Conversely zinc metabolism is influenced by protein deficiency. Zinc takes part in drug metabolism, in mobilizing vitamin A from the liver, and in a system defending the organism against free radical damage. Zinc distribution in the organism is influenced by steroid hormones and leucocytic endogenous mediators.
Effect of Zinc Supplementation in Fracture Healing
Anaesthesist 1975 (Aug); 24 (8): 329–342
After roentgenological, macroscopic and histological examination of healing of fractures of weekly intervals, it was concluded that the Zinc supplementation to an appreciable extent enhanced the process of bone healing which could be further hastened by addition of Vitamin C and Dianabol. No significant toxic or side effect of zinc supplementation was observed in any of the rabbits.
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