US Health Care Spending by Payer and Health Condition, 1996-2016

doi:10.1001/jama.2020.0734

Table 2.

Health Care Estimated Spending in 2016 for the 100 Most Expensive Health Conditions of the 154 Health Conditions Analyzed

Health
Care
Spending
Rank
(High
to Low) Health Condition Category
Code^b Health Care Spending,
2016 $Billion
(95% CI) Estimate, %^a
Aggregated Age Group, y Type of Payer Type of Care Government
Administration
and Net Cost
of Insurance
Programs
<20 20-64 ≥65 Public
Insurance Private
Insurance Out-
of-Pocket
Payments Ambulatory Inpatient Prescribed
Pharmaceuticals Nursing
Care
Facility ED Dental
1 Low back and neck pain A 134.5 (122.4-146.9) 1.9 67.9 30.3 33.7 57.2 9.2 58.7 22.4 3.5 1.4 3.9 0 10.0
2 Other musculoskeletal disorders^c A 129.8 (116.3-149.7) 3.9 60.7 35.4 36.2 56.4 7.5 64.5 8.6 8.7 5.5 2.5 0 10.2
3 Diabetes B 111.2 (105.7-115.9) 2.5 57.4 40.1 49.8 44.2 6.0 27.1 8.6 46.3 5.8 2.1 0 10.1
4 Ischemic heart disease C 89.3 (81.1-95.5) 0.4 42.7 56.9 54.0 42.4 3.5 23.8 49.5 7.5 3.8 5.1 0 10.3
5 Falls F 87.4 (75-100.1) 5.2 38.4 56.4 46.7 39.7 13.6 27.7 31.1 1.1 21.1 9.7 0 9.2
6 Urinary diseases^d B 86.0 (76.3-95.9) 4.1 48.2 47.7 49.2 45.1 5.7 52.0 14.1 7.8 5.1 11.0 0 10.1
7 Skin and subcutaneous diseases^e E 85.0 (80.5-90.2) 15.2 55.3 29.5 35.0 58.0 7.0 54.1 12.3 13.6 3.8 5.9 0 10.2
8 Osteoarthritis A 80.0 (72.2-86.1) 0 50.1 49.9 45.4 49.5 5.1 26.7 49.9 6.1 6.6 0.4 0 10.3
9 Dementias H 79.2 (67.6-90.8) 0 3.1 96.9 56.1 19.2 24.6 2.2 9.3 2.4 77.1 1.2 0 7.8
10 Hypertension M 79.0 (72.6-86.8) 0.7 48.1 51.2 56.9 36.5 6.6 60.1 5.2 12.1 7.1 5.6 0 9.9
11 Oral disorders^f E 76.4 (73.8-79.4) 16.3 58.1 25.6 15.1 45.0 40.0 1.4 1.6 0.7 0 1.0 88.5 6.7
12 Pregnancy and postpartum care^g I 71.3 (64.9-77.7) 2.7 97.3 0 20.9 74.0 5.1 42.0 46.5 0.3 0 0.6 0 10.7
13 Depressive disorders G 67.5 (62.3-72.7) 10.0 75.5 14.5 53.4 37.7 8.9 53.1 12.5 21.2 2.1 1.4 0 9.7
14 Sense organ disorders^h E 64.1 (58.1-69.8) 7.9 35.5 56.7 46.3 41.8 11.9 74.4 2.5 9.6 1.6 2.5 0 9.5
15 Well dental I 60.5 (57.3-63.2) 39.8 44.3 16.0 10.7 54.4 34.9 0 0 0 0 0 92.6 7.4
16 Road injuries F 57.9 (46.7-71.6) 8.7 72.5 18.8 36.2 58.9 4.9 11.8 59.5 0.2 0.7 17.2 0 10.5
17 Other neurological diseasesⁱ H 52.9 (47.1-58.7) 5.2 62.2 32.6 41.7 50.1 8.2 59.3 7.7 11.1 6.3 5.6 0 10.0
18 Septicemia D 52.5 (42.0-62.9) 2.5 53.3 44.2 55.0 40.6 4.4 0 84.6 0 3.1 2.2 0 10.2
19 Other chronic respiratory diseases^j L 45.0 (39.4-50.1) 22.6 57.7 19.7 26.9 65.0 8.1 72.3 4.9 8.0 0.2 4.3 0 10.3
20 Other digestive diseases^k J 44.4 (40.6-49.5) 8.8 54.0 37.2 48.5 45.3 6.1 29.4 19.9 19.8 8.5 12.3 0 10.1
21 Anxiety disorders G 42.4 (37.8-47.7) 9.7 75.3 15.0 49.6 41.2 9.2 55.7 7.0 21.3 2.5 3.8 0 9.7
22 Cerebrovascular disease C 41.9 (37.7-47.1) 1.1 35.8 63.1 56.5 32.8 10.7 4.6 48.1 1.0 32.7 4.1 0 9.4
23 Gynecological diseases^l B 39.4 (35.3-43.3) 2.4 86.3 11.2 18.5 73.5 8.0 51.7 17.1 12.2 0.7 8.0 0 10.4
24 Asthma L 35.5 (32.4-38.2) 22.1 56.8 21.1 41.4 51.5 7.1 21.9 8.6 48.0 1.5 9.9 0 10.1
25 COPD L 34.3 (31.5-37.3) 0.6 35.8 63.6 69.8 24.2 6.0 10.6 28.8 28.5 12.7 9.7 0 9.7
26 Rheumatoid arthritis A 33.8 (28.9-37.7) 17.8 66.1 16.1 36.8 43.2 20.0 6.0 1.1 83.8 0.4 0.1 0 8.7
27 Heart failure C 33.4 (30.7-36.8) 5.1 34.8 60.1 68.0 23.7 8.3 6.9 51.2 11.4 16.5 4.6 0 9.5
28 Endocrine, metabolic, blood, and immune disorders^m B 32.9 (29.9-36.3) 10.1 60.9 28.9 36.3 53.8 9.9 32.4 22.5 26.4 5.7 3.2 0 9.9
29 Cirrhosis N 32.5 (27.0-40.4) 3.6 67.9 28.4 39.9 56.2 3.9 17.4 62.9 2.6 2.3 4.3 0 10.5
30 Lower respiratory tract infections D 32.2 (28.7-35.9) 17.0 43.2 39.8 56.0 37.7 6.4 12.8 51.2 3.9 9.3 12.9 0 9.9
31 Other unintentional injuries F 30.1 (24.3-37.9) 8.3 68.9 22.8 27.2 64.7 8.0 63.0 11.4 1.4 2.0 11.9 0 10.3
32 Injuries due to mechanical forcesⁿ F 28.7 (23.5-34.4) 22.7 62.6 14.6 25.5 65.3 9.2 60.0 11.0 1.9 0.2 16.7 0 10.1
33 Atrial fibrillation and flutter C 28.4 (24.6-33.8) 0 25.0 75.0 56.4 36.9 6.7 29.4 29.8 10.5 15.3 5.1 0 9.9
34 Preterm birth complications^o D 28.2 (21.8-37.6) 100 0 0 25.9 70.0 4.1 7.5 81.5 0 0 0.2 0 10.7
35 Hyperlipidemia M 26.4 (24.3-29.4) 0.6 51.0 48.4 49.1 43.8 7.1 33.4 5.9 45.6 4.7 0.5 0 10.0
36 Other cardiovascular and circulatory diseases^p C 26.2 (22.8-29.9) 3.9 46.8 49.3 53.1 42.7 4.1 37.3 42.8 2.3 3.9 3.5 0 10.2
37 Inflammatory bowel disease J 25.3 (22.3-28.7) 8.6 66.1 25.3 34.2 60.8 5.0 15.5 40.4 12.9 2.6 18.2 0 10.5
38 Nonmelanoma skin cancer K 21.6 (17.7-27.5) 0.5 40.2 59.3 45.1 48.2 6.6 87.8 1.2 0.8 0.1 0 0 10.1
39 Gallbladder and biliary diseases J 20.6 (18.3-23.2) 2.5 71.4 26.1 34.7 61.0 4.2 14.3 52.9 0.3 1.7 20.2 0 10.6
40 Chronic kidney diseases B 19.7 (16.3-22.9) 3.0 45.3 51.7 59.4 37.6 3.0 9.2 72.8 0.3 6.3 1.2 0 10.2
41 Well infant I 17.4 (13.5-21.9) 100 0 0 29.5 67.9 2.6 0 89.1 0 0 0 0 10.9
42 Attention-deficit/hyperactivity disorder G 17.0 (14.4-20.1) 58.2 40.0 1.9 34.3 55.6 10.1 39.4 1.0 49.6 0 0.1 0 9.9
43 HIV/AIDS D 15.7 (12.7-20.0) 16.3 73.4 10.3 78.7 15.3 6.0 2.4 6.7 80.9 0.5 0 0 9.5
44 Other infectious diseases^q D 14.9 (13.0-16.9) 36.8 44.7 18.5 37.2 55.3 7.6 42.8 27.5 7.8 3.7 8.1 0 10.1
45 Congenital anomalies E 14.6 (10.6-18.6) 72.9 20.9 6.3 30.0 65.9 4.1 7.7 80.0 0.6 0.4 0.7 0 10.7
46 Migraine H 14.3 (11.8-17.0) 7.3 86.1 6.6 22.8 69.4 7.8 36.7 6.2 32.8 0.1 13.7 0 10.4
47 Multiple sclerosis H 13.9 (12.6-15.6) 16.6 68.3 15.1 50.9 36.2 13.0 5.1 3.9 76.3 5.4 0.1 0 9.2
48 Bipolar disorder G 13.7 (12.4-15.1) 11.3 75.9 12.8 73.6 21.6 4.7 15.3 44.8 23.5 4.6 1.9 0 9.8
49 Schizophrenia G 13.7 (12.5-15.0) 3.5 75.0 21.5 91.3 4.7 4.0 8.6 58.9 8.5 14.0 0.5 0 9.5
50 Other neoplasms K 13.2 (11.0-15.6) 10.6 55.6 33.7 33.9 60.4 5.7 44.0 42.4 1.0 1.7 0.4 0 10.4
51 Iron-deficiency anemia D 12.8 (11.0-16.2) 4.6 43.8 51.6 53.3 40.6 6.0 19.3 45.2 1.2 19.3 5.1 0 10.0
52 Upper respiratory tract infections D 12.6 (11.3-13.9) 50.2 38.9 10.9 37.0 54.3 8.7 58.1 6.3 3.6 0.3 21.7 0 10.0
53 Drug use disorders^r G 12.5 (10.9-14.1) 3.3 85.1 11.6 71.4 20.0 8.6 59.0 26.1 0.5 0.8 4.3 0 9.4
54 Leukemia K 12.0 (10.7-13.6) 22.7 57.9 19.4 28.6 62.7 8.7 11.3 47.7 29.8 1.0 0 0 10.2
55 Non-Hodgkin lymphoma K 11.8 (10.4-13.4) 15.9 56.7 27.3 22.6 52.2 25.1 14.4 27.4 48.1 1.8 0 0 8.3
56 Endocarditis C 11.5 (10.6-37.9) 2.2 43.1 54.7 51.7 45.6 2.7 8.0 78.9 0.3 2.3 0 0 10.4
57 Indirect maternal complications due to preexisting condition D 11.0 (8.3-13.5) 5.8 94.2 0 37.7 56.2 6.0 2.1 72.9 0.2 0 14.5 0 10.3
58 Well person I 11.0 (9.3-13.0) 31.3 43.7 25.1 34.2 58.3 7.5 88.2 0 1.6 0 0 0 10.2
59 Interpersonal violence F 10.9 (8.2-14.0) 9.8 85.8 4.4 24.7 69.4 5.9 5.2 64.5 0.2 0.1 19.4 0 10.6
60 Hemoglobinopathies; hemolytic anemias B 10.7 (9.6-11.9) 24.2 58.7 17.1 52.3 17.6 30.1 3.1 18.4 70.6 0.2 0.4 0 7.2
61 Colon and rectum cancers K 10.5 (9.3-11.6) 0.6 56.7 42.7 41.8 54.4 3.8 19.7 65.9 0.8 2.8 0.3 0 10.5
62 Morbid obesity M 9.7 (7.2-12.4) 1.9 83.0 15.1 32.8 62.1 5.2 8.0 75.1 2.1 4.2 0.1 0 10.5
63 Otitis media D 9.7 (7.9-12.8) 77.5 15.1 7.5 25.6 65.4 9.0 78.3 1.5 4.4 0.1 5.7 0 10.2
64 Inguinal or femoral hernia J 9.5 (7.7-11.5) 3.7 61.9 34.4 38.2 55.7 6.0 54.5 27.6 1.2 1.0 5.3 0 10.3
65 Appendicitis J 9.3 (8.0-10.8) 27.6 64.1 8.2 23.2 71.1 5.6 3.2 53.2 0 0.2 32.7 0 10.6
66 Paralytic ileus; intestinal obstruction J 9.2 (8.3-11.4) 5.7 45.5 48.9 58.0 38.1 3.8 3.0 73.4 0.1 6.1 7.2 0 10.2
67 Acute renal failure B 9.1 (7.6-10.7) 2.4 32.3 65.3 81.9 14.7 3.4 16.7 59.1 0.9 10.0 3.6 0 9.8
68 Hepatitis D 8.9 (7.9-10.4) 24.1 62.3 13.5 50.7 36.4 12.9 3.8 4.2 82.5 0.2 0.1 0 9.3
69 Epilepsy H 8.6 (7.4-10.0) 23.1 58.5 18.4 63.4 31.5 5.1 12.8 49.2 14.6 3.4 10.1 0 9.9
70 Alcohol use disorders G 8.2 (6.9-9.4) 2.6 79.5 18.0 71.9 22.5 5.5 36.5 46.7 0.2 1.3 5.6 0 9.7
71 Pancreatitis J 7.7 (6.3-9.2) 3.3 73.4 23.3 45.4 48.5 6.1 5.2 75.1 0.3 4.1 5.2 0 10.1
72 Trachea, bronchus, and lung cancers K 7.3 (6.3-8.4) 0.6 44.2 55.2 61.0 35.2 3.8 21.3 61.7 2.7 2.6 1.6 0 10.1
73 Multiple myeloma K 7.1 (6.1-8.5) 3.4 57.9 38.7 37.3 52.5 10.2 28.9 20.2 40.5 0.6 0 0 9.8
74 Peripheral vascular disease C 7.0 (6.1-8.0) 0 34.5 65.5 62.6 32.6 4.7 11.8 56.5 1.1 20.2 0.3 0 10.0
75 Brain and nervous system cancers K 6.8 (6.0-7.6) 14.1 63.7 22.2 28.3 65.3 6.4 7.2 67.1 12.3 2.4 0.6 0 10.4
76 Diarrheal diseases D 6.6 (6.1-7.2) 16.2 47.0 36.8 48.0 45.5 6.5 20.1 51.7 1.8 4.9 11.4 0 10.1
77 Prostate cancer K 5.9 (5.4-6.6) 1.1 48.1 50.8 41.3 52.0 6.8 39.5 37.9 8.4 3.9 0.1 0 10.1
78 Cardiomyopathy; myocarditis C 5.9 (4.5-6.9) 5.7 51.8 42.5 47.4 46.3 6.3 42.8 34.9 8.9 1.4 1.9 0 10.1
79 Aortic aneurysm C 5.6 (5.1-6.2) 1.3 40.5 58.2 62.5 35.3 2.3 7.5 80.2 0 1.8 0.2 0 10.3
80 Hypertensive disorders of pregnancy D 5.5 (4.8-6.3) 5.1 94.9 0 41.4 54.0 4.6 2.8 86.7 0 0 0.1 0 10.4
81 Poisonings F 5.3 (4.5-6.4) 10.7 70.6 18.7 45.5 49.2 5.3 5.4 68.5 0.8 0.4 14.7 0 10.2
82 Other maternal disorders D 5.1 (4.0-6.0) 5.0 95.0 0 28.1 67.9 4.0 1.3 76.7 0.1 0 11.2 0 10.7
83 Breast cancer K 4.5 (3.6-5.5) 0.5 68.6 30.9 34.0 57.9 8.1 31.0 48.9 2.8 5.1 2.1 0 10.1
84 Peptic ulcer disease J 4.5 (3.9-5.7) 1.6 53.1 45.3 53.0 42.8 4.2 6.6 71.2 3.1 5.2 3.7 0 10.2
85 Parkinson disease H 4.5 (3.9-5.2) 0 15.3 84.7 69.5 18.5 11.9 14.3 10.0 12.7 53.9 0.1 0 9.0
86 Obstructed labor D 4.4 (3.8-5.1) 3.6 96.4 0 42.9 52.9 4.2 0 89.6 0 0 0 0 10.4
87 Rheumatic heart disease C 4.3 (1.9-5.6) 4.0 20.5 75.5 65.8 31.9 2.3 9.6 78.4 0 0.8 1.0 0 10.2
88 Family planning I 3.6 (3.0-4.4) 4.6 95.0 0.4 11.0 84.1 4.9 12.8 0.3 76.0 0 0 0 10.9
89 Kidney cancer K 3.4 (2.9-3.9) 9.9 55.2 34.9 49.4 32.0 18.5 18.9 45.5 26.2 0.8 0 0 8.6
90 Gastritis; duodenitis J 3.3 (3.0-3.5) 7.3 61.4 31.3 63.6 29.6 6.9 12.1 40.8 3.3 3.2 31.0 0 9.7
91 Animal contact F 3.2 (2.4-4.4) 24.3 51.0 24.7 37.3 54.0 8.8 56.2 6.8 2.6 0.1 24.3 0 10.0
92 Gout A 2.8 (1.7-5.7) 0.1 36.5 63.4 48.1 37.7 14.2 18.6 14.8 27.2 23.8 6.5 0 9.1
93 Autistic spectrum disorders G 2.7 (2.0-3.3) 72.9 26.1 1.1 57.7 35.4 6.9 81.7 6.7 1.7 0 0 0 9.8
94 Bladder cancer K 2.6 (2.3-2.9) 0.4 30.3 69.2 60.0 35.9 4.1 46.0 37.8 0.9 4.4 0.8 0 10.1
95 Pancreatic cancer K 2.5 (2.2-2.8) 2.0 54.0 44.0 47.8 44.8 7.5 11.7 57.3 19.2 1.8 0 0 9.9
96 Foreign body F 2.5 (2.2-2.8) 39.0 45.0 15.9 42.3 50.3 7.4 26.3 34.9 2.4 0.3 26.1 0 10.1
97 Self-harm F 2.4 (1.7-3.2) 9.4 81.8 8.8 40.6 53.7 5.8 0.8 78.4 0 0.2 10.4 0 10.3
98 Neonatal encephalopathy (birth asphyxia; trauma) D 2.4 (1.8-3.3) 100 0 0 34.3 61.4 4.3 8.0 81.5 0 0 0 0 10.6
99 Other neonatal disorders D 2.2 (1.5-3.0) 100 0 0 35.1 60.4 4.5 9.6 79.5 0 0 0.4 0 10.5
100 Interstitial lung disease; pulmonary sarcoidosis L 2.1 (1.8-2.5) 1.5 51.6 47.0 57.4 38.4 4.2 24.4 62.8 0.2 2.4 0.1 0 10.1

Abbreviations: COPD, chronic obstructive pulmonary disease; ED, emergency department.
a The 95% CIs appear in eTable 12.1 in the Supplement.
b The corresponding aggregated health category descriptions appear in Table 1.
c Includes disorders of the joints, muscular, and connective tissue, including myalgia and osteoporosis.
d Includes urinary tract infection and cyst of kidney.
e Includes cellulitis, sebaceous cyst, acne, and eczema.
f Includes oral surgery and dental caries, including fillings, crowns, extractions, and dentures.
g Includes vaginal and cesarean delivery.
h Includes cataracts, vision correction, adult hearing loss, and macular degeneration.
i Includes pain syndromes and muscular dystrophy.
j Includes sleep apnea, allergic rhinitis, and chronic sinusitis.
k Includes disease of the esophagus and diverticulitis of the colon.
l Includes menopausal and postmenopausal disorders and endometriosis.
m Includes other diseases of the thyroid and von Willebrand disease.
n Includes injuries due to falling objects, being struck by an object, cuts, or being crushed.
o Includes respiratory diseases and extreme neonatal immaturity.
p Includes paroxysmal tachycardia and unspecified dysrhythmias.
q Includes viral and chlamydial infections and streptococcal infection.
r Includes cocaine, opioid, amphetamine, and cannabis dependence.

Health Care Spending Rank (High to Low)	Health Condition	Category Code^b	Health Care Spending, 2016 $Billion (95% CI)	Estimate, %^a
				Aggregated Age Group, y			Type of Payer			Type of Care						Government Administration and Net Cost of Insurance Programs
				<20	20-64	≥65	Public Insurance	Private Insurance	Out- of-Pocket Payments	Ambulatory	Inpatient	Prescribed Pharmaceuticals	Nursing Care Facility	ED	Dental
1	Low back and neck pain	A	134.5 (122.4-146.9)	1.9	67.9	30.3	33.7	57.2	9.2	58.7	22.4	3.5	1.4	3.9	0	10.0
2	Other musculoskeletal disorders^c	A	129.8 (116.3-149.7)	3.9	60.7	35.4	36.2	56.4	7.5	64.5	8.6	8.7	5.5	2.5	0	10.2
3	Diabetes	B	111.2 (105.7-115.9)	2.5	57.4	40.1	49.8	44.2	6.0	27.1	8.6	46.3	5.8	2.1	0	10.1
4	Ischemic heart disease	C	89.3 (81.1-95.5)	0.4	42.7	56.9	54.0	42.4	3.5	23.8	49.5	7.5	3.8	5.1	0	10.3
5	Falls	F	87.4 (75-100.1)	5.2	38.4	56.4	46.7	39.7	13.6	27.7	31.1	1.1	21.1	9.7	0	9.2
6	Urinary diseases^d	B	86.0 (76.3-95.9)	4.1	48.2	47.7	49.2	45.1	5.7	52.0	14.1	7.8	5.1	11.0	0	10.1
7	Skin and subcutaneous diseases^e	E	85.0 (80.5-90.2)	15.2	55.3	29.5	35.0	58.0	7.0	54.1	12.3	13.6	3.8	5.9	0	10.2
8	Osteoarthritis	A	80.0 (72.2-86.1)	0	50.1	49.9	45.4	49.5	5.1	26.7	49.9	6.1	6.6	0.4	0	10.3
9	Dementias	H	79.2 (67.6-90.8)	0	3.1	96.9	56.1	19.2	24.6	2.2	9.3	2.4	77.1	1.2	0	7.8
10	Hypertension	M	79.0 (72.6-86.8)	0.7	48.1	51.2	56.9	36.5	6.6	60.1	5.2	12.1	7.1	5.6	0	9.9
11	Oral disorders^f	E	76.4 (73.8-79.4)	16.3	58.1	25.6	15.1	45.0	40.0	1.4	1.6	0.7	0	1.0	88.5	6.7
12	Pregnancy and postpartum care^g	I	71.3 (64.9-77.7)	2.7	97.3	0	20.9	74.0	5.1	42.0	46.5	0.3	0	0.6	0	10.7
13	Depressive disorders	G	67.5 (62.3-72.7)	10.0	75.5	14.5	53.4	37.7	8.9	53.1	12.5	21.2	2.1	1.4	0	9.7
14	Sense organ disorders^h	E	64.1 (58.1-69.8)	7.9	35.5	56.7	46.3	41.8	11.9	74.4	2.5	9.6	1.6	2.5	0	9.5
15	Well dental	I	60.5 (57.3-63.2)	39.8	44.3	16.0	10.7	54.4	34.9	0	0	0	0	0	92.6	7.4
16	Road injuries	F	57.9 (46.7-71.6)	8.7	72.5	18.8	36.2	58.9	4.9	11.8	59.5	0.2	0.7	17.2	0	10.5
17	Other neurological diseasesⁱ	H	52.9 (47.1-58.7)	5.2	62.2	32.6	41.7	50.1	8.2	59.3	7.7	11.1	6.3	5.6	0	10.0
18	Septicemia	D	52.5 (42.0-62.9)	2.5	53.3	44.2	55.0	40.6	4.4	0	84.6	0	3.1	2.2	0	10.2
19	Other chronic respiratory diseases^j	L	45.0 (39.4-50.1)	22.6	57.7	19.7	26.9	65.0	8.1	72.3	4.9	8.0	0.2	4.3	0	10.3
20	Other digestive diseases^k	J	44.4 (40.6-49.5)	8.8	54.0	37.2	48.5	45.3	6.1	29.4	19.9	19.8	8.5	12.3	0	10.1
21	Anxiety disorders	G	42.4 (37.8-47.7)	9.7	75.3	15.0	49.6	41.2	9.2	55.7	7.0	21.3	2.5	3.8	0	9.7
22	Cerebrovascular disease	C	41.9 (37.7-47.1)	1.1	35.8	63.1	56.5	32.8	10.7	4.6	48.1	1.0	32.7	4.1	0	9.4
23	Gynecological diseases^l	B	39.4 (35.3-43.3)	2.4	86.3	11.2	18.5	73.5	8.0	51.7	17.1	12.2	0.7	8.0	0	10.4
24	Asthma	L	35.5 (32.4-38.2)	22.1	56.8	21.1	41.4	51.5	7.1	21.9	8.6	48.0	1.5	9.9	0	10.1
25	COPD	L	34.3 (31.5-37.3)	0.6	35.8	63.6	69.8	24.2	6.0	10.6	28.8	28.5	12.7	9.7	0	9.7
26	Rheumatoid arthritis	A	33.8 (28.9-37.7)	17.8	66.1	16.1	36.8	43.2	20.0	6.0	1.1	83.8	0.4	0.1	0	8.7
27	Heart failure	C	33.4 (30.7-36.8)	5.1	34.8	60.1	68.0	23.7	8.3	6.9	51.2	11.4	16.5	4.6	0	9.5
28	Endocrine, metabolic, blood, and immune disorders^m	B	32.9 (29.9-36.3)	10.1	60.9	28.9	36.3	53.8	9.9	32.4	22.5	26.4	5.7	3.2	0	9.9
29	Cirrhosis	N	32.5 (27.0-40.4)	3.6	67.9	28.4	39.9	56.2	3.9	17.4	62.9	2.6	2.3	4.3	0	10.5
30	Lower respiratory tract infections	D	32.2 (28.7-35.9)	17.0	43.2	39.8	56.0	37.7	6.4	12.8	51.2	3.9	9.3	12.9	0	9.9
31	Other unintentional injuries	F	30.1 (24.3-37.9)	8.3	68.9	22.8	27.2	64.7	8.0	63.0	11.4	1.4	2.0	11.9	0	10.3
32	Injuries due to mechanical forcesⁿ	F	28.7 (23.5-34.4)	22.7	62.6	14.6	25.5	65.3	9.2	60.0	11.0	1.9	0.2	16.7	0	10.1
33	Atrial fibrillation and flutter	C	28.4 (24.6-33.8)	0	25.0	75.0	56.4	36.9	6.7	29.4	29.8	10.5	15.3	5.1	0	9.9
34	Preterm birth complications^o	D	28.2 (21.8-37.6)	100	0	0	25.9	70.0	4.1	7.5	81.5	0	0	0.2	0	10.7
35	Hyperlipidemia	M	26.4 (24.3-29.4)	0.6	51.0	48.4	49.1	43.8	7.1	33.4	5.9	45.6	4.7	0.5	0	10.0
36	Other cardiovascular and circulatory diseases^p	C	26.2 (22.8-29.9)	3.9	46.8	49.3	53.1	42.7	4.1	37.3	42.8	2.3	3.9	3.5	0	10.2
37	Inflammatory bowel disease	J	25.3 (22.3-28.7)	8.6	66.1	25.3	34.2	60.8	5.0	15.5	40.4	12.9	2.6	18.2	0	10.5
38	Nonmelanoma skin cancer	K	21.6 (17.7-27.5)	0.5	40.2	59.3	45.1	48.2	6.6	87.8	1.2	0.8	0.1	0	0	10.1
39	Gallbladder and biliary diseases	J	20.6 (18.3-23.2)	2.5	71.4	26.1	34.7	61.0	4.2	14.3	52.9	0.3	1.7	20.2	0	10.6
40	Chronic kidney diseases	B	19.7 (16.3-22.9)	3.0	45.3	51.7	59.4	37.6	3.0	9.2	72.8	0.3	6.3	1.2	0	10.2
41	Well infant	I	17.4 (13.5-21.9)	100	0	0	29.5	67.9	2.6	0	89.1	0	0	0	0	10.9
42	Attention-deficit/hyperactivity disorder	G	17.0 (14.4-20.1)	58.2	40.0	1.9	34.3	55.6	10.1	39.4	1.0	49.6	0	0.1	0	9.9
43	HIV/AIDS	D	15.7 (12.7-20.0)	16.3	73.4	10.3	78.7	15.3	6.0	2.4	6.7	80.9	0.5	0	0	9.5
44	Other infectious diseases^q	D	14.9 (13.0-16.9)	36.8	44.7	18.5	37.2	55.3	7.6	42.8	27.5	7.8	3.7	8.1	0	10.1
45	Congenital anomalies	E	14.6 (10.6-18.6)	72.9	20.9	6.3	30.0	65.9	4.1	7.7	80.0	0.6	0.4	0.7	0	10.7
46	Migraine	H	14.3 (11.8-17.0)	7.3	86.1	6.6	22.8	69.4	7.8	36.7	6.2	32.8	0.1	13.7	0	10.4
47	Multiple sclerosis	H	13.9 (12.6-15.6)	16.6	68.3	15.1	50.9	36.2	13.0	5.1	3.9	76.3	5.4	0.1	0	9.2
48	Bipolar disorder	G	13.7 (12.4-15.1)	11.3	75.9	12.8	73.6	21.6	4.7	15.3	44.8	23.5	4.6	1.9	0	9.8
49	Schizophrenia	G	13.7 (12.5-15.0)	3.5	75.0	21.5	91.3	4.7	4.0	8.6	58.9	8.5	14.0	0.5	0	9.5
50	Other neoplasms	K	13.2 (11.0-15.6)	10.6	55.6	33.7	33.9	60.4	5.7	44.0	42.4	1.0	1.7	0.4	0	10.4
51	Iron-deficiency anemia	D	12.8 (11.0-16.2)	4.6	43.8	51.6	53.3	40.6	6.0	19.3	45.2	1.2	19.3	5.1	0	10.0
52	Upper respiratory tract infections	D	12.6 (11.3-13.9)	50.2	38.9	10.9	37.0	54.3	8.7	58.1	6.3	3.6	0.3	21.7	0	10.0
53	Drug use disorders^r	G	12.5 (10.9-14.1)	3.3	85.1	11.6	71.4	20.0	8.6	59.0	26.1	0.5	0.8	4.3	0	9.4
54	Leukemia	K	12.0 (10.7-13.6)	22.7	57.9	19.4	28.6	62.7	8.7	11.3	47.7	29.8	1.0	0	0	10.2
55	Non-Hodgkin lymphoma	K	11.8 (10.4-13.4)	15.9	56.7	27.3	22.6	52.2	25.1	14.4	27.4	48.1	1.8	0	0	8.3
56	Endocarditis	C	11.5 (10.6-37.9)	2.2	43.1	54.7	51.7	45.6	2.7	8.0	78.9	0.3	2.3	0	0	10.4
57	Indirect maternal complications due to preexisting condition	D	11.0 (8.3-13.5)	5.8	94.2	0	37.7	56.2	6.0	2.1	72.9	0.2	0	14.5	0	10.3
58	Well person	I	11.0 (9.3-13.0)	31.3	43.7	25.1	34.2	58.3	7.5	88.2	0	1.6	0	0	0	10.2
59	Interpersonal violence	F	10.9 (8.2-14.0)	9.8	85.8	4.4	24.7	69.4	5.9	5.2	64.5	0.2	0.1	19.4	0	10.6
60	Hemoglobinopathies; hemolytic anemias	B	10.7 (9.6-11.9)	24.2	58.7	17.1	52.3	17.6	30.1	3.1	18.4	70.6	0.2	0.4	0	7.2
61	Colon and rectum cancers	K	10.5 (9.3-11.6)	0.6	56.7	42.7	41.8	54.4	3.8	19.7	65.9	0.8	2.8	0.3	0	10.5
62	Morbid obesity	M	9.7 (7.2-12.4)	1.9	83.0	15.1	32.8	62.1	5.2	8.0	75.1	2.1	4.2	0.1	0	10.5
63	Otitis media	D	9.7 (7.9-12.8)	77.5	15.1	7.5	25.6	65.4	9.0	78.3	1.5	4.4	0.1	5.7	0	10.2
64	Inguinal or femoral hernia	J	9.5 (7.7-11.5)	3.7	61.9	34.4	38.2	55.7	6.0	54.5	27.6	1.2	1.0	5.3	0	10.3
65	Appendicitis	J	9.3 (8.0-10.8)	27.6	64.1	8.2	23.2	71.1	5.6	3.2	53.2	0	0.2	32.7	0	10.6
66	Paralytic ileus; intestinal obstruction	J	9.2 (8.3-11.4)	5.7	45.5	48.9	58.0	38.1	3.8	3.0	73.4	0.1	6.1	7.2	0	10.2
67	Acute renal failure	B	9.1 (7.6-10.7)	2.4	32.3	65.3	81.9	14.7	3.4	16.7	59.1	0.9	10.0	3.6	0	9.8
68	Hepatitis	D	8.9 (7.9-10.4)	24.1	62.3	13.5	50.7	36.4	12.9	3.8	4.2	82.5	0.2	0.1	0	9.3
69	Epilepsy	H	8.6 (7.4-10.0)	23.1	58.5	18.4	63.4	31.5	5.1	12.8	49.2	14.6	3.4	10.1	0	9.9
70	Alcohol use disorders	G	8.2 (6.9-9.4)	2.6	79.5	18.0	71.9	22.5	5.5	36.5	46.7	0.2	1.3	5.6	0	9.7
71	Pancreatitis	J	7.7 (6.3-9.2)	3.3	73.4	23.3	45.4	48.5	6.1	5.2	75.1	0.3	4.1	5.2	0	10.1
72	Trachea, bronchus, and lung cancers	K	7.3 (6.3-8.4)	0.6	44.2	55.2	61.0	35.2	3.8	21.3	61.7	2.7	2.6	1.6	0	10.1
73	Multiple myeloma	K	7.1 (6.1-8.5)	3.4	57.9	38.7	37.3	52.5	10.2	28.9	20.2	40.5	0.6	0	0	9.8
74	Peripheral vascular disease	C	7.0 (6.1-8.0)	0	34.5	65.5	62.6	32.6	4.7	11.8	56.5	1.1	20.2	0.3	0	10.0
75	Brain and nervous system cancers	K	6.8 (6.0-7.6)	14.1	63.7	22.2	28.3	65.3	6.4	7.2	67.1	12.3	2.4	0.6	0	10.4
76	Diarrheal diseases	D	6.6 (6.1-7.2)	16.2	47.0	36.8	48.0	45.5	6.5	20.1	51.7	1.8	4.9	11.4	0	10.1
77	Prostate cancer	K	5.9 (5.4-6.6)	1.1	48.1	50.8	41.3	52.0	6.8	39.5	37.9	8.4	3.9	0.1	0	10.1
78	Cardiomyopathy; myocarditis	C	5.9 (4.5-6.9)	5.7	51.8	42.5	47.4	46.3	6.3	42.8	34.9	8.9	1.4	1.9	0	10.1
79	Aortic aneurysm	C	5.6 (5.1-6.2)	1.3	40.5	58.2	62.5	35.3	2.3	7.5	80.2	0	1.8	0.2	0	10.3
80	Hypertensive disorders of pregnancy	D	5.5 (4.8-6.3)	5.1	94.9	0	41.4	54.0	4.6	2.8	86.7	0	0	0.1	0	10.4
81	Poisonings	F	5.3 (4.5-6.4)	10.7	70.6	18.7	45.5	49.2	5.3	5.4	68.5	0.8	0.4	14.7	0	10.2
82	Other maternal disorders	D	5.1 (4.0-6.0)	5.0	95.0	0	28.1	67.9	4.0	1.3	76.7	0.1	0	11.2	0	10.7
83	Breast cancer	K	4.5 (3.6-5.5)	0.5	68.6	30.9	34.0	57.9	8.1	31.0	48.9	2.8	5.1	2.1	0	10.1
84	Peptic ulcer disease	J	4.5 (3.9-5.7)	1.6	53.1	45.3	53.0	42.8	4.2	6.6	71.2	3.1	5.2	3.7	0	10.2
85	Parkinson disease	H	4.5 (3.9-5.2)	0	15.3	84.7	69.5	18.5	11.9	14.3	10.0	12.7	53.9	0.1	0	9.0
86	Obstructed labor	D	4.4 (3.8-5.1)	3.6	96.4	0	42.9	52.9	4.2	0	89.6	0	0	0	0	10.4
87	Rheumatic heart disease	C	4.3 (1.9-5.6)	4.0	20.5	75.5	65.8	31.9	2.3	9.6	78.4	0	0.8	1.0	0	10.2
88	Family planning	I	3.6 (3.0-4.4)	4.6	95.0	0.4	11.0	84.1	4.9	12.8	0.3	76.0	0	0	0	10.9
89	Kidney cancer	K	3.4 (2.9-3.9)	9.9	55.2	34.9	49.4	32.0	18.5	18.9	45.5	26.2	0.8	0	0	8.6
90	Gastritis; duodenitis	J	3.3 (3.0-3.5)	7.3	61.4	31.3	63.6	29.6	6.9	12.1	40.8	3.3	3.2	31.0	0	9.7
91	Animal contact	F	3.2 (2.4-4.4)	24.3	51.0	24.7	37.3	54.0	8.8	56.2	6.8	2.6	0.1	24.3	0	10.0
92	Gout	A	2.8 (1.7-5.7)	0.1	36.5	63.4	48.1	37.7	14.2	18.6	14.8	27.2	23.8	6.5	0	9.1
93	Autistic spectrum disorders	G	2.7 (2.0-3.3)	72.9	26.1	1.1	57.7	35.4	6.9	81.7	6.7	1.7	0	0	0	9.8
94	Bladder cancer	K	2.6 (2.3-2.9)	0.4	30.3	69.2	60.0	35.9	4.1	46.0	37.8	0.9	4.4	0.8	0	10.1
95	Pancreatic cancer	K	2.5 (2.2-2.8)	2.0	54.0	44.0	47.8	44.8	7.5	11.7	57.3	19.2	1.8	0	0	9.9
96	Foreign body	F	2.5 (2.2-2.8)	39.0	45.0	15.9	42.3	50.3	7.4	26.3	34.9	2.4	0.3	26.1	0	10.1
97	Self-harm	F	2.4 (1.7-3.2)	9.4	81.8	8.8	40.6	53.7	5.8	0.8	78.4	0	0.2	10.4	0	10.3
98	Neonatal encephalopathy (birth asphyxia; trauma)	D	2.4 (1.8-3.3)	100	0	0	34.3	61.4	4.3	8.0	81.5	0	0	0	0	10.6
99	Other neonatal disorders	D	2.2 (1.5-3.0)	100	0	0	35.1	60.4	4.5	9.6	79.5	0	0	0.4	0	10.5
100	Interstitial lung disease; pulmonary sarcoidosis	L	2.1 (1.8-2.5)	1.5	51.6	47.0	57.4	38.4	4.2	24.4	62.8	0.2	2.4	0.1	0	10.1