Soybean-Derived Phytoalexins Improve Cognitive Function through Activation of Nrf2/HO-1 Signaling Pathway

doi:10.3390/ijms19010268

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Int J Mol Sci. 2018 Jan; 19(1): 268.

Published online 2018 Jan 16. doi: 10.3390/ijms19010268

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Figure 5

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Effect of inhibitors of MAPK, PI3K on Nrf2 transcriptional activation by glyceollins, as evaluated by reporter assay. SHSY5Y-ARE or HT22-ARE cell lines were treated with glyceollins in the presence or absence of inhibitors for MAPK and PI3K for 16 h followed by measuring luciferase activity. Bars represent mean ± SD (n = 4). *, Significantly different from the untreated control (p < 0.05) in SHSY5Y-ARE cells. #, Significantly different from the untreated control (p < 0.05) in HT22-ARE cells.