Table 5
Summary of the pre-clinical and clinical evidence supporting magnesium status on stress susceptibility. a Only symptoms shown in ≥70% of women at baseline are reported.
| Evidence of the Impact of Magnesium Status on Stress Susceptibility | ||||
|---|---|---|---|---|
| Population Tested | Mg Status | Stress Stimulus | Impact on Stress Mediator/Stress | |
| Pre-clinical | Rats (N = 84) | Mg-deficient | Noise | ↑Catecholamines (NA, adrenaline, dopamine) [136] |
| Mice (N = 120) | Mg-deficient | Genetic selection | ↑NA [137] | |
| Mice (N = 80) | Mg-deficient | Genetic selection; forced swimming test; four-plate test | ↑NA [138] | |
| Mice (N = 100) | Mg-deficient | Genetic selection; immobilization test | ↑Gastric ulcers [139] | |
| Mice (N = 20/test) | Dietary Mg restriction | Hyperthermia; open field test; light/dark test; hyponeophagia test | ↑CRH; ↑ACHT [140] | |
| Mice | Mg-deficient | Light/dark test | Depression-like behavior [42,140] | |
| Rats | Dietary Mg restriction | Forced swimming test | Depression-like behavior [142,143] | |
| Rats | Dietary Mg restriction | Open field test | Stress/anxiety [142,143] | |
| Clinical | Women (N = 100) | Mg-deficient | - | Chronic emotional stress; irritability; fatigue; sleep disturbance; headache a [144] |
| Adults (N = 264) | Mg-deficient | - | Severe stress [78,145,146] | |
| Adults (N = 100) | Mg-deficient | Poor sleep quality | ↑CRP [145] | |
| Adults (N = 109) | Mg-deficient | - | Depression/anxiety [148] | |