Table 2

Difference between groups in the primary and secondary outcome measures.

Outcome	Time	Mean Difference ± SE [95% CI]	p-Value
Primary:
FMA	4 weeks	6.1 ± 2.9 [0.4, 11.9]	0.04 *
	8 weeks	4.5 ± 3.4 [−2.2, 11.2]	0.2
Secondary:
FMA-UE	4 weeks	2.9 ± 2.5 [−2.0, 7.9]	0.2
	8 weeks	3.0 ± 2.9 [−2.8, 8.8]	0.3
FMA-LE	4 weeks	2.9 ± 1.2 [0.5, 5.3]	0.02 *
	8 weeks	1.9 ± 1.4 [−0.9, 4.6]	0.2
SS-QOL	4 weeks	−9.2 ± 10.4 [−30.0, 11.5]	0.4
	8 weeks	16.7 ± 11.5 [−6.2, 39.6]	0.2
TUG	4 weeks	−1.2 ± 2.2 [−5.5, 3.2]	0.6
	8 weeks	0.9 ± 2.7 [−4.4, 6.2]	0.7
mRS	4 weeks	0.0 ± 0.3 [−0.5, 0.5]	0.9
	8 weeks	0.1 ± 0.3 [−0.4, 0.6]	0.7
STS	4 weeks	−1.5 ± 4.2 [−9.6, 6.6]	0.7
	8 weeks	1.0 ± 4.6 [−8.0, 9.9]	0.8

Mean difference = chiro + PT − sham + PT, * denotes the null hypothesis is rejected. These marginal mean differences were estimated by the statistical models by holding the baseline scores constant across the two groups, except in the case of 5SST for which adjustment was done by subtracting baseline means from the follow-up means. For 5SST, mean difference is defined as [chiro + PT − (chiro + PT) Baseline] − [sham + PT − (sham + PT) Baseline]. FMA, Fugal-Meyer Assessment; UE, upper extremity; LE, lower extremity; SS-QOL, Stroke Specific Quality of Life; TUG, Time Up and Go; mRS, Modified Rankin Scale; STS, Sit-to-Stand Test.