Vitamin C, Reflex Sympathetic Dystrophy and Complex Regional Pain Syndrome

Vitamin C, Reflex Sympathetic Dystrophy
and Complex Regional Pain Syndrome

This section is compiled by Frank M. Painter, D.C.
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Complex regional pain syndrome (CRPS), formerly known as Reflex Sympathetic Dystrophy or Causalgia, is a chronic progressive disease characterized by severe pain, swelling, and changes in the skin.   It often affects an arm or a leg and may spread to another part of the body and is associated with dysregulation of the autonomic nervous system resulting in multiple functional loss, impairment, and disability.   Though treatment is often unsatisfactory, early multimodal therapy may cause dramatic improvement or remission of the syndrome in some patients.

The International Association for the Study of Pain has proposed dividing CRPS into two types based on the presence of nerve lesion following the injury.

  • Type I, formerly known as reflex sympathetic dystrophy (RSD), Sudeck's atrophy, reflex neurovascular dystrophy (RND), or algoneurodystrophy, does not have demonstrable nerve lesions.

  • Type II, formerly known as causalgia, has evidence of obvious nerve damage.

The actual cause of this syndrome is currently unknown.   Precipitating factors include injury and surgery, although there are documented cases that have no demonstrable injury at the original site.

From:  Dynamic Chiropractic ~ April 9, 2010 ~ FULL TEXT

By G. Douglas Andersen, DC, DACBSP, CCN

When I was in school, I remember being told that reflex sympathetic dystrophy (RSD) was the modern term for causalgia, a condition first described by doctors during the Civil War.

After graduation, I recall attending a seminar and learning that causalgia was the correct term to use if RSD was severe. Because of the confusion surrounding these two terms (as well as others), the condition was re-named in the mid 1990s to complex regional pain syndrome (CRPS), with CRPS Type 1 replacing RSD and CRPS Type 2 replacing causalgia. The differences were that the nerve dysfunction in CRPS Type 1 patients stemmed from traumas like sprains, fractures and surgeries, in which there was no direct nerve damage. The CRPS Type 2 label was reserved for those with a direct nerve injury. (However, due to the fact that the symptoms of the two classes do not differ, many doctors and therapists continue to call the condition RSD.)

Characteristics of CRPS

CRPS is most likely to occur following trauma to an extremity that requires immobilization, such as a fracture, surgery or gunshot wound. However, it can even occur after a minor sprain or even a blood draw. The hallmark symptoms are intense burning pain and extreme skin sensitivity. A host of skin changes can also occur. (Table 1) Joint stiffness, muscle contractions, weakness and muscle atrophy can occur after three or more months.

Table 1: Skin Changes in the Area of CRPS*

Shiny appearance
Sweatiness or moistness
Redness, white color, blue color
Increased temperature or decreased temperature
Increased hair growth or hair loss

*Not all changes are seen in all patients.

Vitamin C for CRPS: What Recent Research Suggests

The authors of a 2009 study [1] called it a "quasi experiment" because it compared the outcomes of 392 patients in successive years who had foot and ankle surgeries. The first group (July 2002 - June 2003) numbered 177 patients; the second group (July 2003 - June 2004) included 215 patients. Patients in the second group only were given 1,000 mg of vitamin C a day for 46 consecutive days following their surgery. Study findings are shown in Table 2.

Table 2: Post-Op Vitamin C and CRPS Incidence
No Vitamin
Vitamin C
Number of Patients
CRPS Cases
% CRPS Cases

The results of this "quasi experiment" mirror an earlier study in 2007 [2] involving wrist fractures, in which there was a 10 percent rate of CRPS in patients given placebo, a 1.8 percent rate of CRPS in patients given 500 mg of vitamin C and a 1.7 percent incidence of CRPS in a third group given 1,500 mg vitamin C for 50 days after their wrist injuries.

Practice Recommendations

Based on these two studies, the simple addition of 500 mg of vitamin C a day for two months following extremity trauma appears to reduce of the incidence of CRPS by 80 percent. Whether you practice nutrition or not, anytime you have a patient who has a upper or lower limb injury requiring casting or surgical repair, remind them to take some extra vitamin C. Not only will it help healing by its well-recognized effect on collagen formation and free-radical reduction, but it also just may prevent CRPS. And as anyone who has had a CRPS patient will tell you, the best treatment is prevention.


  1. Effect of vitamin C on prevention of complex regional pain syndrome type 1 in foot and ankle surgery
    Foot Ankle Surg. 2009;   15 (4):   179-82.   Epub 2009 Apr 5

  2. Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized controlled multicenter dose-response study
    J Bone Joint Surg (U.S.), 2007;   (89):   1424-1431

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