Multivitamin and Mineral Supplementation in
1,2-dimethylhydrazine Induced Experimental Colon
Carcinogenesis and Evaluation of Free Radical Status,
Antioxidant Potential, and Incidence of ACF

This section is compiled by Frank M. Painter, D.C.
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FROM: Canadian Journal of Physiology and Pharmacology 2012 (Jan);   90 (1):   45–54 ~ FULL TEXT

Albert Baskar Arul, Ignacimuthu Savarimuthu, Mohammed A. Alsaif, Khalid S. Al Numaira

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.

Regular Vitamin and Mineral Supplementation Use Lowers Colon Cancer Risk By Eighty-four Percent Source: Natural News Researchers publishing in the Canadian Journal of Physiology and Pharmacology (CJPP) have found that a diet enhanced with vitamin and mineral supplementation can lower the risk of developing precancerous colon cancer lesions by up to 84%. Colon cancer is the second most common form of the disease affecting men and women in the US, with nearly 150,000 new diagnoses each year. Nutrition experts and alternative practitioners understand that cancer is largely a disease caused by poor lifestyle behaviors including a diet lacking an optimal intake of vitamins and minerals. Chronic illnesses including colon cancer are the result of many years and decades of low nutritional status, as support for a healthy immune response is suppressed. Scientists now provide compelling evidence in support of whole-food based vitamin and mineral supplementation to dramatically lower the risk of colorectal cancer. Vitamin and Mineral Supplements Help Significantly Lower Colorectal Cancer Risk The study authors used rats that were fed a high fat diet (20% fat intake) for a period of 32 weeks. Rats are commonly used for this type of research because they develop colon cancer polyps and tumors in a manner parallel to humans. The rats were divided into six groups and were subsequently exposed to different combinations of carcinogens and nutritional supplements. The researchers found that the animals fed a high-fat, low fiber diet and exposed to a carcinogen developed pre-cancerous lesions of the colon along a pathway similar to that found in humans. The group of animals that underwent a similar treatment and diet, but were supplemented with a daily vitamin and mineral supplement showed an 84% reduction in the formation of pre-cancerous lesions and did not develop tumors. This study is key as it demonstrates the importance of building a solid nutrient base over time to saturate cells and tissues in order to prevent common diseases such as colon cancer. The research authors concluded "multivitamin and mineral supplements synergistically contribute to the cancer chemo-preventative potential, and hence, regular supplements of multivitamins and minerals could reduce the risk of colon cancer." Health-minded individuals know the importance of obtaining a full range of vitamins and minerals from fresh, raw or minimally cooked foods to promote health. Extensive research is now mounting to suggest that higher amounts of nutrients obtained from a whole food organic vitamin and mineral supplement may be necessary to achieve optimal health and convey maximum protection against colon cancer.

The Abstract:

This study was performed to determine the chemopreventive and antioxidant status of multivitamin and mineral (0.01% in drinking water, ad libitum) supplements in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis. Experimental colon carcinogenesis was induced in male albino Wistar rats by injecting DMH (20 mg·(kg body mass)(-1)) once weekly for 15 consecutive weeks, and administering a multivitamin supplement in 3 regimes (initiation, post-initiation, and entire experimental period) for 32 weeks. We studied lipid peroxidation products (thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) in the circulation and in the tissues, antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and non-enzymatic antioxidant-reduced glutathione) of the tissues, aberrant crypt foci (ACF), and histopathological alterations. DMH-induced rats had an increase in lipid peroxidation products and a lower antioxidant status compared with control animals. Multivitamin and mineral supplementation during the initiation, post-initiation, and the entire study period significantly decreased the levels of lipid peroxidation products in circulation and colonic tissues, significantly elevated the activities of the antioxidant enzymes and reduced glutathione to near normalcy in DMH-induced rats. The incidence of ACF was reduced to 84.1% in rats supplemented with multivitamin and minerals for the entire study and prevented the colonic tissue from histopathological alterations induced by DMH.

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